(r)-(3-carboxy-2-hydroxypropyl)-trimethyl ammonium orotate
L-Carnitine orotate
CAS: 160468-17-7
Molecular Formula: C12H17N3O6
(r)-(3-carboxy-2-hydroxypropyl)-trimethyl ammonium orotate - Names and Identifiers
(r)-(3-carboxy-2-hydroxypropyl)-trimethyl ammonium orotate - Physico-chemical Properties
| Molecular Formula | C12H17N3O6 |
| Molar Mass | 299.28 |
| Melting Point | 180-187°C |
| Solubility | DMSO (Slightly, Heated), Water (Slightly) |
| Appearance | Solid |
| Color | White to Off-White |
| Storage Condition | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| Stability | Hygroscopic |
(r)-(3-carboxy-2-hydroxypropyl)-trimethyl ammonium orotate - Reference Information
| Pharmacological effects | L-carnitine orotin is an ionic complex salt formed by pharmacologically active L-carnitine and orotic acid. It is easier to absorb than the original forms of L-carnitine and orotic acid after entering the body. Orotic acid can normalize the proliferation of liver cells and the liver enzyme system. L-carnitine, as a biological stimulant of fat metabolism, can promote the oxidation process of free fatty acids in the liver. L-carnitine lactate can play an effective role as a pro-fat factor It can be used in the adjuvant treatment of various diseases such as hepatitis, liver cirrhosis, fatty liver, liver poisoning, and liver function damage caused by alcohol. |
| preparation | (1) dissolve 156g(1mol) of orotic acid in 2000mL of water, raise the temperature to 80 ℃, add 1.2mol of ammonia water with a mass percentage concentration of 25% under stirring, keep the above temperature for 1.5 hours, after the reaction is completed, concentrate, cool down and crystallide, and filter to obtain ammonium orotic acid salt;(2) Add the obtained ammonium salt of rootate to 2700mL of ethanol aqueous solution, where the mass percentage of ethanol is 10%, raise the temperature to 80 ℃ to dissolve the clear lactic acid salt, then add 241.8g of L-carnitine, keep the temperature at this temperature for 3 hours, cool down to 0 ℃, precipitate the product, and filter to obtain 296g of L-carnitine lactate. After liquid phase detection, the retention time of the product was compared with the L-carnitine lactinate standard, and the product was determined to be L-carnitine lactinate. The content was determined by liquid phase naturalization method: Agilent 1100 high performance liquid chromatography was used. The liquid column used was Agilent SB C8(150mm × 4.6mm, 5 μm), mobile phase: 0.02mol/L phosphoric acid solution, flow rate: 1.0 ml/min, temperature: 30 ℃, detection wavelength: 254nm, retention time of L-carnitine lactate: 4.95 minutes, yield of 93.4%, and L-carnitine lactate content of 99.5%. |
Last Update：2024-04-10 22:41:03
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CAS: 160468-17-7
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CAS: 160468-17-7
Tel: 18301782025
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Mobile: 18021002903
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